Serine-threonine kinases in TCR signaling

Nat Immunol. 2014 Sep;15(9):808-14. doi: 10.1038/ni.2941.


T lymphocyte proliferation and differentiation are controlled by signaling pathways initiated by the T cell antigen receptor. Here we explore how key serine-threonine kinases and their substrates mediate T cell signaling and coordinate T cell metabolism to meet the metabolic demands of participating in an immune response.

Publication types

  • Review

MeSH terms

  • Cell Differentiation / immunology*
  • Cell Proliferation / physiology*
  • Humans
  • Lymphocyte Activation / immunology
  • Protein-Serine-Threonine Kinases / immunology*
  • Receptors, Antigen, T-Cell / immunology*
  • Signal Transduction / immunology*
  • T-Lymphocytes / immunology*


  • Receptors, Antigen, T-Cell
  • Protein-Serine-Threonine Kinases