Multiciliogenesis: multicilin directs transcriptional activation of centriole formation

Fernando R Balestra; Pierre Gönczy

doi:10.1016/j.cub.2014.07.006

Multiciliogenesis: multicilin directs transcriptional activation of centriole formation

Curr Biol. 2014 Aug 18;24(16):R746-9. doi: 10.1016/j.cub.2014.07.006.

Authors

Fernando R Balestra¹, Pierre Gönczy²

Affiliations

¹ Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland.
² Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland. Electronic address: pierre.gonczy@epfl.ch.

PMID: 25137586
DOI: 10.1016/j.cub.2014.07.006

Abstract

During differentiation of multiciliated cells, numerous centrioles are generated in each cell to act as templates for the formation of a corresponding number of cilia. A new study reveals that multicilin, a protein required for multiciliogenesis, is a key component of a regulatory complex that activates the transcription of genes required for centriole formation.

Publication types

Comment

MeSH terms

Animals
Centrioles / metabolism*
E2F Transcription Factors / metabolism*
Xenopus Proteins / metabolism*

Substances

E2F Transcription Factors
Xenopus Proteins