Increased serum levels of interleukin-18, -23 and -17 in Chinese patients with Alzheimer's disease

Dement Geriatr Cogn Disord. 2014;38(5-6):321-9. doi: 10.1159/000360606. Epub 2014 Aug 13.


Aims: To evaluate the serum levels of interleukin (IL)-18, IL-23 and IL-17 in Chinese patients with Alzheimer's disease (AD), and explore correlations between the three cytokines and relevant parameters.

Methods: Serum concentrations of IL-18, IL-23 and IL-17 were measured by ELISA for 53 AD patients and 53 sex- and age-matched healthy controls in a community of elderly individuals in a Shanghai suburb.

Results: Serum concentrations of IL-18, IL-23 and IL-17 were significantly higher in AD patients than controls. The serum level of IL-23 was observed to be significantly higher (p = 0.049) in female AD patients than male AD patients. In addition, a significantly inverse correlation was found between IL-18 and MMSE score (rs = -0.356, p = 0.011) for all AD patients.

Conclusion: Elevated IL-18, IL-23 and IL-17 levels are observed in AD patients and differences may exist between males and females. Besides, IL-18 may correlate with the severity of AD.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Alzheimer Disease / blood*
  • Alzheimer Disease / psychology
  • Asian Continental Ancestry Group
  • China
  • Female
  • Humans
  • Interleukin-17 / blood*
  • Interleukin-18 / blood*
  • Interleukin-23 / blood*
  • Male
  • Mental Status Schedule
  • Sex Factors


  • Interleukin-17
  • Interleukin-18
  • Interleukin-23