High usage of topical fusidic acid and rapid clonal expansion of fusidic acid-resistant Staphylococcus aureus: a cautionary tale

Clin Infect Dis. 2014 Nov 15;59(10):1451-4. doi: 10.1093/cid/ciu658. Epub 2014 Aug 18.


Our aim was to assess national prescribing trends and determine longitudinal resistance patterns for topical antimicrobials in New Zealand. We observed a dramatic increase in fusidic acid (FA) resistance, and clonal expansion of FA-resistant Staphylococcus aureus. This increase was concurrent with a significant national increase in topical FA dispensing.

Keywords: MRSA; antimicrobial resistance; antimicrobial use; epidemiology; fusC.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Topical
  • Anti-Bacterial Agents / administration & dosage
  • Anti-Bacterial Agents / therapeutic use*
  • Drug Prescriptions / statistics & numerical data*
  • Drug Resistance, Bacterial*
  • Fusidic Acid / administration & dosage
  • Fusidic Acid / therapeutic use*
  • Humans
  • New Zealand
  • Staphylococcal Infections / drug therapy*
  • Staphylococcal Infections / microbiology
  • Staphylococcus aureus / drug effects*


  • Anti-Bacterial Agents
  • Fusidic Acid