Low-level Viremia early in HIV infection

doi:10.1097/QAI.0000000000000298

. 2014 Dec 1;67(4):405-8.

doi: 10.1097/QAI.0000000000000298.

Low-level Viremia early in HIV infection

Iris Chen¹, Vanessa Cummings, Jessica M Fogel, Mark A Marzinke, William Clarke, Matthew B Connor, Sam Griffith, Susan Buchbinder, Steven Shoptaw, Carlos Del Rio, Manya Magnus, Sharon Mannheimer, Darrell P Wheeler, Kenneth H Mayer, Beryl A Koblin, Susan H Eshleman

Affiliations

Affiliation

¹ *Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD; †Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA; ‡Science Facilitation Department, FHI 360, Research Triangle Park, NC; §San Francisco Department of Public Health, Bridge HIV, San Francisco, CA; ‖Department of Family Medicine, University of California Los Angeles, Los Angeles, CA; ¶Department of Global Health, Emory University Rollins School of Public Health, Atlanta, GA; #Department of Epidemiology and Biostatistics, The George Washington University, Washington, DC; **Department of Medicine, Harlem Hospital, Columbia University, Mailman School of Public Health, New York, NY; ††Graduate School of Social Work, Loyola University Chicago, Chicago, IL; ‡‡The Fenway Institute, Fenway Health/Infectious Disease Division, Beth Israel Deaconess Medical Center/Department of Medicine, Harvard Medical School, Boston, MA; §§Laboratory of Infectious Disease Prevention, Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY.

PMID: 25140905
PMCID: PMC4213245
DOI: 10.1097/QAI.0000000000000298

Low-level Viremia early in HIV infection

Iris Chen et al. J Acquir Immune Defic Syndr. 2014.

. 2014 Dec 1;67(4):405-8.

doi: 10.1097/QAI.0000000000000298.

Authors

Affiliation

¹ *Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD; †Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA; ‡Science Facilitation Department, FHI 360, Research Triangle Park, NC; §San Francisco Department of Public Health, Bridge HIV, San Francisco, CA; ‖Department of Family Medicine, University of California Los Angeles, Los Angeles, CA; ¶Department of Global Health, Emory University Rollins School of Public Health, Atlanta, GA; #Department of Epidemiology and Biostatistics, The George Washington University, Washington, DC; **Department of Medicine, Harlem Hospital, Columbia University, Mailman School of Public Health, New York, NY; ††Graduate School of Social Work, Loyola University Chicago, Chicago, IL; ‡‡The Fenway Institute, Fenway Health/Infectious Disease Division, Beth Israel Deaconess Medical Center/Department of Medicine, Harvard Medical School, Boston, MA; §§Laboratory of Infectious Disease Prevention, Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY.

PMID: 25140905
PMCID: PMC4213245
DOI: 10.1097/QAI.0000000000000298

Abstract

HIV RNA levels are usually high early in HIV infection. In the HPTN 061 study, men were tested for HIV infection every 6 months; 6 (21.4%) of 28 men who acquired HIV infection during the study had low or undetectable HIV RNA at the time of HIV diagnosis. Antiretroviral drugs were not detected at the time of HIV diagnosis. False-negative HIV test results were obtained for 2 men using multiple assays. Antiretroviral drug resistance mutations were detected in HIV from 1 man. Additional studies are needed to identify factors associated with low HIV RNA levels during early HIV infection.

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References

1. Fiebig EW, Wright DJ, Rawal BD, et al. Dynamics of HIV viremia and antibody seroconversion in plasma donors: implications for diagnosis and staging of primary HIV infection. AIDS. 2003;17:1871–1879. - PubMed
1. Walker BD, Yu XG. Unravelling the mechanisms of durable control of HIV-1. Nat Rev Immunol. 2013;13:487–498. - PubMed
1. Okulicz JF, Marconi VC, Landrum ML, et al. Clinical outcomes of elite controllers, viremic controllers, and long-term nonprogressors in the US Department of Defense HIV natural history study. J Infect Dis. 2009;200:1714–1723. - PubMed
1. Madec Y, Boufassa F, Porter K, Meyer L. Spontaneous control of viral load and CD4 cell count progression among HIV-1 seroconverters. AIDS. 2005;19:2001–2007. - PubMed
1. Miura T, Brumme ZL, Brockman MA, et al. Impaired replication capacity of acute/early viruses in persons who become HIV controllers. J Virol. 2010;84:7581–7591. - PMC - PubMed

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[1] Fiebig EW, Wright DJ, Rawal BD, et al. Dynamics of HIV viremia and antibody seroconversion in plasma donors: implications for diagnosis and staging of primary HIV infection. AIDS. 2003;17:1871–1879. - PubMed

[2] Fiebig EW, Wright DJ, Rawal BD, et al. Dynamics of HIV viremia and antibody seroconversion in plasma donors: implications for diagnosis and staging of primary HIV infection. AIDS. 2003;17:1871–1879. - PubMed

[3] Walker BD, Yu XG. Unravelling the mechanisms of durable control of HIV-1. Nat Rev Immunol. 2013;13:487–498. - PubMed

[4] Walker BD, Yu XG. Unravelling the mechanisms of durable control of HIV-1. Nat Rev Immunol. 2013;13:487–498. - PubMed

[5] Okulicz JF, Marconi VC, Landrum ML, et al. Clinical outcomes of elite controllers, viremic controllers, and long-term nonprogressors in the US Department of Defense HIV natural history study. J Infect Dis. 2009;200:1714–1723. - PubMed

[6] Okulicz JF, Marconi VC, Landrum ML, et al. Clinical outcomes of elite controllers, viremic controllers, and long-term nonprogressors in the US Department of Defense HIV natural history study. J Infect Dis. 2009;200:1714–1723. - PubMed

[7] Madec Y, Boufassa F, Porter K, Meyer L. Spontaneous control of viral load and CD4 cell count progression among HIV-1 seroconverters. AIDS. 2005;19:2001–2007. - PubMed

[8] Madec Y, Boufassa F, Porter K, Meyer L. Spontaneous control of viral load and CD4 cell count progression among HIV-1 seroconverters. AIDS. 2005;19:2001–2007. - PubMed

[9] Miura T, Brumme ZL, Brockman MA, et al. Impaired replication capacity of acute/early viruses in persons who become HIV controllers. J Virol. 2010;84:7581–7591. - PMC - PubMed

[10] Miura T, Brumme ZL, Brockman MA, et al. Impaired replication capacity of acute/early viruses in persons who become HIV controllers. J Virol. 2010;84:7581–7591. - PMC - PubMed

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Low-level Viremia early in HIV infection

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