Genetic markers of cisplatin-induced hearing loss in children

Clin Pharmacol Ther. 2014 Sep;96(3):296-8. doi: 10.1038/clpt.2014.92.


This journal recently published a Commentary by Ratain and colleagues at the University of Chicago that criticizes our work on cisplatin-induced hearing loss in children. It is unfortunate that neither the authors nor the editors of Clinical Pharmacology & Therapeutics corresponded with us to provide an earlier opportunity to address these questions. Here we correct the authors' inaccuracies and provide additional analyses that further strengthen our published findings.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Antineoplastic Agents / adverse effects*
  • Antineoplastic Agents / toxicity*
  • Catechol O-Methyltransferase / genetics*
  • Cisplatin / adverse effects*
  • Cisplatin / toxicity*
  • Female
  • Genetic Variation*
  • Hearing Loss / chemically induced*
  • Hearing Loss / genetics*
  • Humans
  • Male
  • Methyltransferases / genetics*
  • Multidrug Resistance-Associated Proteins / genetics*


  • Antineoplastic Agents
  • Multidrug Resistance-Associated Proteins
  • Methyltransferases
  • Catechol O-Methyltransferase
  • Cisplatin