Expert opinion on the cough hypersensitivity syndrome in respiratory medicine

Eur Respir J. 2014 Nov;44(5):1132-48. doi: 10.1183/09031936.00218613. Epub 2014 Aug 19.


In 2011, a European Respiratory Society Task Force embarked on a process to determine the position and clinical relevance of the cough hypersensitivity syndrome, a disorder characterised by troublesome coughing often triggered by low levels of thermal, mechanical or chemical exposure, in the management of patients with chronic cough. A 21-component questionnaire was developed by an iterative process supported by a literature review. 44 key opinion leaders in respiratory medicine were selected and interviewed as to their opinions. There was a high degree of unanimity in the responses obtained, with all opinion leaders supporting the concept of cough hypersensitivity as a clinically useful paradigm. The classic stratification of cough into asthmatic, rhinitic and reflux-related phenotypes was supported. Significant disparity of opinion was seen in the response to two questions concerning the therapy of chronic cough. First, the role of acid suppression in reflux cough was questioned. Secondly, the opinion leaders were split as to whether a trial of oral steroids was indicated to establish a diagnosis of eosinophilic cough. The cough hypersensitivity syndrome was clearly endorsed by the opinion leaders as a valid and useful concept. They considered that support of patients with chronic cough was inadequate and the Task Force recommends that further work is urgently required in this neglected area.

MeSH terms

  • Bronchitis / diagnosis
  • Chronic Disease
  • Congresses as Topic
  • Cough / diagnosis*
  • Cough / physiopathology*
  • Diagnosis, Differential
  • Eosinophilia / diagnosis
  • Europe
  • Humans
  • Hypersensitivity
  • Inflammation
  • Pulmonary Medicine / methods*
  • Respiratory System / innervation
  • Societies, Medical
  • Steroids / therapeutic use
  • Surveys and Questionnaires
  • Symptom Assessment


  • Steroids