Dietary fermented soybean suppresses UVB-induced skin inflammation in hairless mice via regulation of the MAPK signaling pathway

J Agric Food Chem. 2014 Sep 10;62(36):8962-72. doi: 10.1021/jf5018252. Epub 2014 Aug 29.


Soybean may be a promising ingredient for regulating UVB-induced inflammatory damage to the skin. We investigated the anti-inflammatory effects of diets supplemented with fermented soybean on UVB-induced skin photodamage and the effectiveness of soybean (S) and fermented soybean (FS) dietary supplementation. To investigate the effects of two major isoflavones-daidzein and genistein-from FS, we used cocultures with keratinocytes and fibroblasts. Genistein treatment strongly inhibited the production of IL-6 and MAPK signaling. Forty hairless male mice divided into four groups were fed with a control diet (group N: normal, group C; +UVB) or diets with 2.5% S+UVB or 2.5% FS+UVB (group S, group FS) for 8 weeks. Macrophage infiltration to the dermis was reduced more in groups S and FS than in group C. The expression levels of iNOS and COX-2 were significantly decreased in group FS (by 7.7% ± 0.4% and 21.2% ± 0.3%, respectively [p < 0.05]).

Keywords: dietary supplementation; fermented soybean; skin inflammation; soybean; ultraviolet B (UVB).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Inflammatory Agents*
  • Coculture Techniques
  • Cyclooxygenase 2 Inhibitors
  • Dermatitis / etiology*
  • Dermatitis / therapy*
  • Diet*
  • Dietary Supplements
  • Fermentation*
  • Fibroblasts
  • Genistein / administration & dosage
  • Humans
  • Isoflavones / administration & dosage
  • Keratinocytes
  • Male
  • Mice
  • Mice, Hairless
  • Nitric Oxide Synthase Type II / antagonists & inhibitors
  • Signal Transduction / drug effects
  • Soybeans*
  • Ultraviolet Rays


  • Anti-Inflammatory Agents
  • Cyclooxygenase 2 Inhibitors
  • Isoflavones
  • daidzein
  • Genistein
  • Nitric Oxide Synthase Type II