Use of interferon-gamma release assays to calculate the annual risk of tuberculosis infection

Pediatr Infect Dis J. 2015 Feb;34(2):219-21. doi: 10.1097/INF.0000000000000514.

Abstract

The objective was to assess the annual risk of tuberculosis infection by means of tuberculin skin testing (TST) in children, evaluating whether QuantiFERON-TB Gold In-Tube (QFN-G-IT) could improve the accuracy. On the basis of the positive TST results, the global annual incidence was estimated at 0.78%, with an increase in the prevalence from 0.64% to 1.68% in 2 years. However, QFN-G-IT was only positive in 6 of the 25 children with positive TST. The confirmation of the positive TST results by QFN-G-IT provided more accurate annual incidence estimation.

Publication types

  • Evaluation Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Child
  • Cohort Studies
  • Cross-Sectional Studies
  • Diagnostic Tests, Routine / methods*
  • Female
  • Humans
  • Incidence
  • Interferon-gamma Release Tests / methods*
  • Male
  • Prevalence
  • Risk Assessment
  • Spain / epidemiology
  • Tuberculin Test / methods
  • Tuberculosis / diagnosis*
  • Tuberculosis / epidemiology*