Congenital methemoglobinemia in a dog with a promoter deletion and a nonsynonymous coding variant in the gene encoding cytochrome b₅

J A McKenna; J Sacco; T T Son; L A Trepanier; M B Callan; J W Harvey; J W Arndt

doi:10.1111/jvim.12423

Congenital methemoglobinemia in a dog with a promoter deletion and a nonsynonymous coding variant in the gene encoding cytochrome b₅

J Vet Intern Med. 2014 Sep-Oct;28(5):1626-31. doi: 10.1111/jvim.12423. Epub 2014 Aug 21.

Authors

J A McKenna¹, J Sacco, T T Son, L A Trepanier, M B Callan, J W Harvey, J W Arndt

Affiliation

¹ Department of Emergency and Critical Care, Advanced Critical Care, Emergency & Specialty Services - Los Angeles, Culver City, CA.

No abstract available

Keywords: Cyanosis; Cytochrome b5 reductase; Methemoglobin reductase; Methylene blue; Nicotinamide adenine dinucleotide phosphate methemoglobin reductase.

Publication types

Case Reports

MeSH terms

Animals
Cytochrome-B(5) Reductase / metabolism
Cytochromes b5 / deficiency*
Cytochromes b5 / genetics*
Dog Diseases / congenital
Dog Diseases / drug therapy
Dog Diseases / genetics*
Dogs
Enzyme Inhibitors / therapeutic use
Gene Deletion
Male
Methemoglobinemia / congenital
Methemoglobinemia / drug therapy
Methemoglobinemia / genetics
Methemoglobinemia / veterinary*
Methylene Blue / therapeutic use
Open Reading Frames / genetics
Polymorphism, Genetic / genetics
Promoter Regions, Genetic / genetics

Substances

Enzyme Inhibitors
Cytochromes b5
Cytochrome-B(5) Reductase
Methylene Blue

Supplementary concepts

Methemoglobinemia Type IV