Lysyl oxidase in cancer research

Future Oncol. 2014;10(9):1709-17. doi: 10.2217/fon.14.39.


Metastasis is the main reason for cancer-associated deaths and therapies are desperately needed to target the progression of cancer. Lysyl oxidase (LOX) plays a pivotal role in cancer progression, including metastasis, and is therefore is an attractive therapeutic target. In this review we will breakdown the process of cancer progression and the various roles that LOX plays has in the advancement of cancer. We will highlight why LOX is an exciting therapeutic target for the future.

Keywords: angiogenesis; cancer; extracellular matrix; lysyl oxidase; metastasis; premetastatic niche; prognostic markers; stroma; therapeutic targets.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Biomedical Research
  • Humans
  • Neoplasm Metastasis
  • Neoplasms / enzymology*
  • Neoplasms / pathology
  • Protein Processing, Post-Translational
  • Protein-Lysine 6-Oxidase / physiology*
  • Tumor Suppressor Proteins / physiology


  • Tumor Suppressor Proteins
  • Protein-Lysine 6-Oxidase