Circulating miR-1, miR-133a, and miR-206 levels are increased after a half-marathon run

Biomarkers. 2014 Nov;19(7):585-9. doi: 10.3109/1354750X.2014.952663. Epub 2014 Aug 22.


Context: Circulating miRNAs are potential biomarkers that can be important molecules driving cell-to-cell communication.

Objective: To investigate circulating muscle-specific miRNAs in recreational athletes.

Materials and methods: Three miRNAs from whole plasma before and after a half-marathon were analyzed by qPCR.

Results: MiR-1, -133a, and -206 significantly increased after the race.

Discussion: Increased levels of miRNAs after exercise point to potential biomarkers and to the possibility of being functional players following endurance training.

Conclusion: These miRNAs are potential biomarkers of muscle damage or adaptation to exercise.

Keywords: Exercise; extracellular vesicles; microRNA; plasma; quantitative PCR.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Genetic Markers
  • Humans
  • Male
  • MicroRNAs / blood*
  • Physical Endurance / genetics*
  • Real-Time Polymerase Chain Reaction
  • Running*
  • Time Factors
  • Up-Regulation


  • Genetic Markers
  • MIRN1 microRNA, human
  • MIRN133 microRNA, human
  • MIRN206 microRNA, human
  • MicroRNAs