Human lysyl oxidase-like 2

Bioorg Chem. 2014 Dec;57:231-241. doi: 10.1016/j.bioorg.2014.07.003. Epub 2014 Aug 1.


Lysyl oxidase like-2 (LOXL2) belongs to the lysyl oxidase (LOX) family, which comprises Cu(2+)- and lysine tyrosylquinone (LTQ)-dependent amine oxidases. LOXL2 is proposed to function similarly to LOX in the extracellular matrix (ECM) by promoting crosslinking of collagen and elastin. LOXL2 has also been proposed to regulate extracellular and intracellular cell signaling pathways. Dysregulation of LOXL2 has been linked to many diseases, including cancer, pro-oncogenic angiogenesis, fibrosis and heart diseases. In this review, we will give an overview of the current understandings and hypotheses regarding the molecular functions of LOXL2.

Keywords: Cell signaling; Extracellular matrix; Lysine tyrosylquinone (LTQ); Lysyl oxidase family; Lysyl oxidase like-2; Tumor metastasis/invasion.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acid Oxidoreductases / chemistry*
  • Amino Acid Oxidoreductases / metabolism*
  • Breast / enzymology
  • Breast / pathology
  • Breast Neoplasms / enzymology
  • Breast Neoplasms / pathology
  • Copper / chemistry
  • Copper / metabolism
  • Female
  • Humans
  • Models, Molecular


  • Copper
  • Amino Acid Oxidoreductases
  • LOXL2 protein, human