Hijacked by an oocyte: hierarchical molecular changes in somatic cell nuclear transfer

Itay Maza; Jacob H Hanna

doi:10.1016/j.molcel.2014.08.008

Hijacked by an oocyte: hierarchical molecular changes in somatic cell nuclear transfer

Mol Cell. 2014 Aug 21;55(4):507-9. doi: 10.1016/j.molcel.2014.08.008.

Authors

Itay Maza¹, Jacob H Hanna²

Affiliations

¹ The Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel.
² The Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel. Electronic address: jacob.hanna@weizmann.ac.il.

PMID: 25148360
DOI: 10.1016/j.molcel.2014.08.008

Abstract

Xenopus oocytes can epigenetically reprogram mouse somatic cells toward totipotency. In this issue, Jullien et al. (2014) now describe rapid, interdependent molecular events that facilitate this reprogramming.

Publication types

Comment

MeSH terms

Animals
Cellular Reprogramming / genetics*
Chromatin / metabolism*
Histones / physiology*
Oocytes / metabolism*
Xenopus / embryology*

Substances

Chromatin
Histones