Mathematical models of mitochondrial aging and dynamics

Prog Mol Biol Transl Sci. 2014;127:63-92. doi: 10.1016/B978-0-12-394625-6.00003-9.


Research on the role of mitochondria in aging and disease is rapidly growing. Furthermore, in recent years, it also became clear that mitochondria are dynamic structures undergoing constant and rapid cycles of fusion and fission. The involvement of mitochondria in multiple complex processes makes them a prime target for mathematical and computational modeling. This review consists of two parts. In the first (Section 2), we provide a detailed introduction to the underlying concepts of mathematical modeling to help the reader who is not so familiar with these techniques to judge the requirements and results that can be obtained through modeling. In the second part (Section 3), we review existing mathematical and computational models that investigate mitochondrial dynamics and the role of mitochondria for the aging process.

Keywords: Aging; Computer simulation; Mathematical model; Mitochondria; Systems biology.

Publication types

  • Review

MeSH terms

  • Aging / metabolism*
  • Humans
  • Mitochondria / metabolism*
  • Mitochondrial Dynamics*
  • Models, Biological*
  • Mutation / genetics