Early Life Permethrin Exposure Leads to Hypervitaminosis D, Nitric Oxide and Catecholamines Impairment

Pestic Biochem Physiol. 2013 Sep;107(1):93-7. doi: 10.1016/j.pestbp.2013.05.010. Epub 2013 May 30.


The aim of this study is to gain more knowledge on the impact of early life pesticide exposure on premature aging. The effect of a low dose of the insecticide permethrin administered to rats during early life (1/50 LD50, from 6th to 21st day of life) was analyzed by measuring some metabolites in plasma and urine of 500-day-old animals. Significant differences in early life treated rats compared to the control group were found in the plasma levels of Ca(++), Na(+), 25-hydroxy-vitamin D, adrenaline, noradrenaline, nitric oxide, cholesterol and urea while in urine only Na(+) content was different. These results add information on the impact of permethrin during the neonatal period, supporting the evidence that early life environmental exposure to xenobiotics has long-term effects, inducing modifications in adulthood that can be revealed by the analysis of some macroelements, metabolites and catecholamines in plasma, when rats are 500 days old.

Keywords: 25-Hydroxy-vitamin D; Calcium; Catecholamines; Early life permethrin treatment; NO; Rat.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aging / blood
  • Aging / urine
  • Animals
  • Animals, Newborn
  • Calcium / blood
  • Calcium / urine
  • Catecholamines / blood
  • Catecholamines / urine
  • Female
  • Glucose / analysis
  • Hydrocortisone / blood
  • Insecticides / toxicity*
  • Male
  • Nitric Oxide / blood
  • Permethrin / toxicity*
  • Potassium / blood
  • Potassium / urine
  • Rats, Wistar
  • Sodium / blood
  • Sodium / urine
  • Urea / blood
  • Vitamin D / blood


  • Catecholamines
  • Insecticides
  • Vitamin D
  • Nitric Oxide
  • Permethrin
  • Urea
  • Sodium
  • Glucose
  • Potassium
  • Calcium
  • Hydrocortisone