Hypercoagulability in celiac disease--an update

Autoimmun Rev. 2014 Nov;13(11):1138-41. doi: 10.1016/j.autrev.2014.07.004. Epub 2014 Aug 20.


Celiac disease is a life-long autoimmune disease affecting multiple organs of genetically susceptible individuals. One of the extra intestinal manifestations of the disease is thromboembolic events like strokes, veins' thrombosis, and pregnancy losses. Hypercoagulable autoimmune diseases like lupus erythematosus and antiphospholipid syndrome, associated with celiac disease just add risk to the patients. Pathogenic predisposing avenues increasing the hypercoagulability in celiac disease are multiple: nutritional deficiencies (B12, folate, and vitamin K), genetic predisposition (MTHFR mutations), thrombophilic autoantibodies, hyperhomocysinemia, endothelial dysfunction and platelet abnormalities. Primary pharmacologic thromboprophylaxis or treating the predisposing factors should be considered on a personal basis.

Keywords: Autoimmunity; Celiac disease; Hypercoagulability; Thromboembolism; Thrombophilia.

Publication types

  • Review

MeSH terms

  • Autoantibodies
  • Autoimmune Diseases
  • Celiac Disease / etiology*
  • Humans
  • Methylenetetrahydrofolate Reductase (NADPH2) / genetics
  • Mutation
  • Thrombophilia / etiology*


  • Autoantibodies
  • MTHFR protein, human
  • Methylenetetrahydrofolate Reductase (NADPH2)