Coenzyme Q10 and α-tocopherol reversed age-associated functional impairments in mice

Exp Gerontol. 2014 Oct;58:208-18. doi: 10.1016/j.exger.2014.08.007. Epub 2014 Aug 19.

Abstract

The purpose of this study was to determine if intake of the antioxidants coenzyme Q10 (CoQ10) or α-tocopherol (Toc), either alone or in combination, could ameliorate cognitive and psychomotor impairments of aged mice, as well as reduce oxidative burden in tissues. For a period of 10 weeks, male C57BL/6J mice (3 or 18 months) were fed either a control diet, or one of three diets supplemented with Toc, CoQ10 or their combination, and were tested for cognitive and psychomotor functions. Old mice on the Toc or Toc/CoQ10 diets showed improved coordinated running performance. Mice on the diet containing Toc/CoQ10 demonstrated improved performance in the discriminated avoidance task. CoQ10 and Toc alone also resulted in improved performance, albeit to a lesser degree. Protein damage was decreased especially when the mice received Toc+CoQ10 combination. Overall, these results suggest that, Toc and CoQ supplementation can ameliorate age-related impairment and reduce protein oxidation. Moreover, concurrent supplementation of CoQ10 and Toc may be more effective than either antioxidant alone.

Keywords: Antioxidants; Behavior; Coenzyme Q(10); Cognitive function; Mitochondria; Motor function; Oxidative stress; Vitamin E.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Age Factors
  • Aging / metabolism
  • Aging / psychology*
  • Animals
  • Antioxidants / pharmacology*
  • Behavior, Animal / drug effects*
  • Body Weight / drug effects
  • Cognition / drug effects*
  • Dietary Supplements*
  • Eating / drug effects
  • Male
  • Mice, Inbred C57BL
  • Mitochondria / drug effects
  • Mitochondria / metabolism
  • Motor Activity / drug effects*
  • Oxidative Stress / drug effects
  • Protein Carbonylation
  • Psychomotor Performance / drug effects*
  • Time Factors
  • Ubiquinone / analogs & derivatives*
  • Ubiquinone / pharmacology
  • alpha-Tocopherol / pharmacology*

Substances

  • Antioxidants
  • Ubiquinone
  • coenzyme Q10
  • alpha-Tocopherol