Pro-inflammatory cytokines: emerging players regulating HSC function in normal and diseased hematopoiesis

Exp Cell Res. 2014 Dec 10;329(2):248-54. doi: 10.1016/j.yexcr.2014.08.017. Epub 2014 Aug 19.


Hematopoiesis is the hierarchical process in which all lineages of blood cells are produced by self-renewing hematopoietic stem cells (HSCs) in the bone marrow (BM). While the regulatory factors that maintain proper HSC function and lineage output under normal conditions are well understood, significantly less is known about how HSC fate is regulated in response to inflammation or disease. As many blood disorders are associated with overproduction of pro-inflammatory cytokines, significant interest has emerged in understanding the impact of these factors on HSC function. In this review we highlight key advances demonstrating the impact of pro-inflammatory cytokines on the biology of HSCs and the BM niche, and address ongoing questions regarding their role in normal and pathogenic hematopoiesis.

Keywords: Cytokine; Hematopoietic stem cell; Inflammation; Interferon; Interleukin; Myeloproliferative neoplasm.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Differentiation / drug effects
  • Cytokines / pharmacology*
  • Hematologic Diseases / drug therapy
  • Hematologic Diseases / immunology
  • Hematologic Diseases / pathology*
  • Hematopoiesis / physiology*
  • Hematopoietic Stem Cells / cytology*
  • Hematopoietic Stem Cells / drug effects
  • Hematopoietic Stem Cells / immunology
  • Humans
  • Inflammation Mediators / metabolism*


  • Cytokines
  • Inflammation Mediators