Genetics of obsessive-compulsive disorder and related disorders

Psychiatr Clin North Am. 2014 Sep;37(3):319-35. doi: 10.1016/j.psc.2014.06.002. Epub 2014 Jul 23.


Twin and family studies support a significant genetic contribution to obsessive-compulsive disorder (OCD) and related disorders, such as chronic tic disorders, trichotillomania, skin-picking disorder, body dysmorphic disorder, and hoarding disorder. Recently, population-based studies and novel laboratory-based methods have confirmed substantial heritability in OCD. Genome-wide association studies and candidate gene association studies have provided information on specific gene variations that may be involved in the pathobiology of OCD, though a substantial portion of the genetic risk architecture remains unknown.

Keywords: Candidate gene; Familial recurrence; GWAS; Genetics; Heritability; Model system; OCD; Twin study.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Body Dysmorphic Disorders / genetics*
  • Chronic Disease
  • Disease Models, Animal
  • Diseases in Twins / genetics
  • Family Health
  • Genetic Association Studies / methods
  • Humans
  • Obsessive-Compulsive Disorder / genetics*
  • Recurrence
  • Tic Disorders / genetics*
  • Tourette Syndrome / genetics*
  • Trichotillomania / genetics*