Immunomodulatory effects of EGCG fraction of green tea extract in innate and adaptive immunity via T regulatory cells in murine model

Immunopharmacol Immunotoxicol. 2014 Oct;36(5):364-70. doi: 10.3109/08923973.2014.953637. Epub 2014 Aug 25.


Green tea is a widely consumed beverage known for its beneficial anti-inflammatory, anti-oxidative, anti-mutagenic, anti-carcinogenic, and cardioprotective properties. Here, we administered epigallocatechin gallate fraction of green tea extract (EGTE) to mice for 6 weeks and examined the effects on the innate and adaptive immune responses by measuring phagocytic and natural killer (NK) cell activity, as well as antigen-specific proliferation, cytolysis, cytokine secretion, and antibody production. Our data show that EGTE administration increased NK cell cytolysis and peritoneal cell phagocytosis, as well as splenocyte proliferation and secretion of IL-2 and IFN-γ. Of note, EGTE treatment decreased the production antigen-specific IgE via increased the proportion of CD4+ CD25+ regulatory T lymphocytes in the spleen, suggesting that EGTE may play a role in regulating the allergic response.

Keywords: EGCG fraction of green tea; IgE; NK cytolysis; Treg; phagocytosis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adaptive Immunity / drug effects*
  • Animals
  • B-Lymphocytes / drug effects
  • Catechin / analogs & derivatives*
  • Catechin / chemistry
  • Catechin / pharmacology
  • Cell Proliferation / drug effects
  • Female
  • Immunity, Innate / drug effects*
  • Killer Cells, Natural / drug effects
  • Mice
  • Mice, Inbred BALB C
  • Ovalbumin / immunology
  • Phagocytes / drug effects
  • Phagocytosis / drug effects
  • Plant Extracts / chemistry*
  • Plant Extracts / pharmacology*
  • T-Lymphocytes, Regulatory / drug effects*
  • T-Lymphocytes, Regulatory / immunology*
  • Tea / chemistry*


  • Plant Extracts
  • Tea
  • Catechin
  • Ovalbumin
  • epigallocatechin gallate