Oral medications

Dermatol Clin. 2014 Oct;32(4):527-32. doi: 10.1016/j.det.2014.06.002. Epub 2014 Jul 29.


Primary hyperhidrosis commonly affects the axillae, palms, soles, scalp, face, and groin. Patients may have multiple areas involved making localized therapy challenging. Systemic therapy may be necessary and can be used as monotherapy or combined with other hyperhidrosis treatments for optimal outcomes. Systemic therapy can also be used to treat secondary hyperhidrosis and compensatory hyperhidrosis.

Keywords: Anticholinergic; Clonidine; Glycopyrrolate; Hyperhidrosis; Oxybutynin; Propanolol; Systemic therapy; β-blocker.

Publication types

  • Review

MeSH terms

  • Administration, Oral
  • Adrenergic beta-Antagonists / administration & dosage*
  • Cholinergic Antagonists / administration & dosage*
  • Humans
  • Hyperhidrosis / drug therapy*
  • Treatment Outcome


  • Adrenergic beta-Antagonists
  • Cholinergic Antagonists