Studies of the in vitro antibacterial activities of several polyphenols against clinical isolates of methicillin-resistant Staphylococcus aureus

Molecules. 2014 Aug 19;19(8):12630-9. doi: 10.3390/molecules190812630.

Abstract

In this study, we report the antibacterial activities of six polyphenols (i.e., luteolin, quercetin, scutellarin, apigenin, chlorogenic acid, and resveratrol) against 29 clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA), and in vitro antibacterial activities of two-drug combinations. All of the MRSA strains evaluated were clinical isolates from patients with MRSA bacteremia. The antibacterial activities were determined by agar dilution method, and the two-drug antibacterial activities were determined by the checkerboard agar dilution method. It was found that luteolin, quercetin and resveratrol show obvious antibacterial activities against MRSA, and the results of two-drug antibacterial activity show either synergy or additivity, without evidences of antagonistic effects.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Bacteremia / microbiology
  • Drug Synergism
  • Humans
  • Luteolin / pharmacology*
  • Methicillin-Resistant Staphylococcus aureus / drug effects*
  • Methicillin-Resistant Staphylococcus aureus / isolation & purification
  • Microbial Sensitivity Tests
  • Polyphenols / pharmacology
  • Quercetin / pharmacology*
  • Resveratrol
  • Staphylococcal Infections / microbiology
  • Stilbenes / pharmacology*

Substances

  • Anti-Bacterial Agents
  • Polyphenols
  • Stilbenes
  • Quercetin
  • Luteolin
  • Resveratrol