Copaiba oil suppresses inflammatory cytokines in splenocytes of C57Bl/6 mice induced with experimental autoimmune encephalomyelitis (EAE)

Molecules. 2014 Aug 21;19(8):12814-26. doi: 10.3390/molecules190812814.


Experimental autoimmune encephalomyelitis (EAE) is a murine autoimmune disease used to study multiple sclerosis. We have investigated the immunomodulatory effects of copaiba oil (100, 50 and 25 µg/mL) on NO, H2O2, TNF-α, IFN-γ and IL-17 production in cultured cells from EAE-mice. Copaiba oil (100 µg/mL) inhibited H2O2, NO, IFN-γ TNF-α and IL-17 production spontaneously or after ConA and MOG35-55 stimulation. It is suggested that copaiba oil acts on the mechanism of development of EAE by IFN-γ, IL-17 and TNF-α inhibition, modulating the immune response on both Th1 and Th17 cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Inflammatory Agents / pharmacology*
  • Cells, Cultured
  • Cytokines / metabolism*
  • Drug Evaluation, Preclinical
  • Encephalomyelitis, Autoimmune, Experimental / drug therapy*
  • Encephalomyelitis, Autoimmune, Experimental / immunology
  • Fabaceae / chemistry
  • Female
  • Hydrogen Peroxide / metabolism
  • Mice, Inbred C57BL
  • Nitric Oxide / metabolism
  • Plant Oils / pharmacology*
  • Spleen / pathology*


  • Anti-Inflammatory Agents
  • Cytokines
  • Plant Oils
  • Nitric Oxide
  • Hydrogen Peroxide