The Associations Between Serum Zinc Levels and Metabolic Syndrome in the Korean Population: Findings From the 2010 Korean National Health and Nutrition Examination Survey

PLoS One. 2014 Aug 25;9(8):e105990. doi: 10.1371/journal.pone.0105990. eCollection 2014.


The prevalence of metabolic syndrome has been increasing rapidly worldwide. The functions of zinc may have a potential association with metabolic syndrome, but such associations have not been investigated extensively. Therefore, we examined the relationship between serum zinc levels and metabolic syndrome or metabolic risk factors among South Korean adults ≥ 20 years of age. The analysis used data from the Korean National Health and Nutrition Examination Survey, a cross-sectional survey of Korean civilians, conducted from January to December 2010. A total of 1,926 participants were analyzed in this study. Serum zinc levels in men were negatively associated with elevated fasting glucose (adjusted odds ratio [aOR], 0.58; 95% confidence interval [CI], 0.36-0.93) and positively associated with elevated triglycerides (aOR, 1.47; 95% CI, 1.01-2.13). A difference in serum zinc levels was detected in women, depending on the number of metabolic syndrome components (p = 0.002). Furthermore, serum zinc levels showed a decreasing trend with increasing numbers of metabolic syndrome components in women with metabolic syndrome. These findings suggest that serum zinc levels might be associated with metabolic syndrome or metabolic risk factors. Further gender-specific studies are needed to evaluate the effect of dietary or supplemental zinc intake on metabolic syndrome.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Cross-Sectional Studies
  • Female
  • Humans
  • Male
  • Metabolic Syndrome / blood*
  • Metabolic Syndrome / epidemiology*
  • Middle Aged
  • Nutrition Surveys
  • Prevalence
  • Republic of Korea / epidemiology
  • Risk Factors
  • Sex Factors
  • Young Adult
  • Zinc / blood*


  • Zinc

Grant support

The authors have no support or funding to report.