Human cytomegalovirus intrahost evolution-a new avenue for understanding and controlling herpesvirus infections

Curr Opin Virol. 2014 Oct:8:109-15. doi: 10.1016/j.coviro.2014.08.001. Epub 2014 Aug 25.


Human cytomegalovirus (HCMV) is exquisitely adapted to the human host, and much research has focused on its evolution over long timescales spanning millennia. Here, we review recent data exploring the evolution of the virus on much shorter timescales, on the order of days or months. We describe the intrahost genetic diversity of the virus isolated from humans, and how this diversity contributes to HCMV spatiotemporal evolution. We propose mechanisms to explain the high levels of intrahost diversity and discuss how this new information may shed light on HCMV infection and pathogenesis.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Cytomegalovirus / classification*
  • Cytomegalovirus / genetics*
  • Cytomegalovirus / isolation & purification
  • Cytomegalovirus Infections / virology*
  • Evolution, Molecular*
  • Genetic Variation*
  • Humans
  • Spatio-Temporal Analysis