Taming the young and restless--epigenetic gene regulation in pancreas and beta-cell precursors

EMBO J. 2014 Oct 1;33(19):2135-6. doi: 10.15252/embj.201489751. Epub 2014 Aug 25.


The in vivo assessment of epigenetic changes during mouse pancreatic beta‐cell differentiation reveals surprising differences to directed, in vitro differentiation of human embryonic stem cells. New findings reported in this issue of The EMBO Journal further identify Ezh2 as a critical determinant of endocrine progenitor number and could instruct improved protocols for stem cell-based therapies.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Animals
  • Endocrine Cells / cytology*
  • Enhancer of Zeste Homolog 2 Protein
  • Histones / metabolism*
  • Humans
  • Islets of Langerhans / cytology*
  • Jumonji Domain-Containing Histone Demethylases / genetics*
  • Polycomb Repressive Complex 2 / physiology*


  • Histones
  • Jumonji Domain-Containing Histone Demethylases
  • Kdm6b protein, mouse
  • Enhancer of Zeste Homolog 2 Protein
  • Ezh2 protein, mouse
  • Polycomb Repressive Complex 2