Whole blood metal ion measurement reproducibility between different laboratories

J Arthroplasty. 2014 Nov;29(11):2214-8. doi: 10.1016/j.arth.2014.07.018. Epub 2014 Jul 24.


Monitoring patients' metal ion blood concentrations can be useful in cases of problematic metal on metal hip implants. Our objective was to evaluate the reproducibility of metal ion level values measured by two different laboratories. Whole blood samples were collected in 46 patients with metal on metal hip arthroplasty. For each patients, two whole blood samples were collected and analyzed by two laboratories. Laboratory 1 had higher results than laboratory 2. There was a clinically significant absolute difference between the two laboratories, above the predetermined threshold, 35% of Cr samples and 38% of Co samples. All laboratories do not use the same technologies for their measurements. Therefore, decision to revise a metal on metal hip arthroplasty should rely on metal ion trends and have to be done in the same laboratory.

Keywords: arthroplasty; chromium; cobalt; hip; ion; metal.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Aged
  • Arthroplasty, Replacement, Hip / adverse effects*
  • Chromium / blood
  • Cobalt / blood
  • Female
  • Hip Prosthesis / adverse effects*
  • Humans
  • Ions / blood
  • Laboratories / standards
  • Male
  • Metal-on-Metal Joint Prostheses / adverse effects*
  • Metals, Heavy / blood*
  • Middle Aged
  • Prosthesis Design
  • Prosthesis Failure
  • Reproducibility of Results


  • Ions
  • Metals, Heavy
  • Chromium
  • Cobalt