Acute kidney injury in the neonate

Clin Perinatol. 2014 Sep;41(3):487-502. doi: 10.1016/j.clp.2014.05.001. Epub 2014 Jul 22.


Critically ill neonates are at risk for acute kidney injury (AKI). AKI has been associated with increased risk of morbidity and mortality in adult and pediatric patients, and increasing evidence suggests a similar association in the neonatal population. This article describes the current AKI definitions (including their limitations), work on novel biomarkers to define AKI, diagnosis and management strategies, long-term outcomes after AKI, and future directions for much-needed research in this important area.

Keywords: Acute kidney injury; Acute renal failure; Biomarkers; Chronic kidney disease; Critical illness; Neonate.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Acute Kidney Injury* / diagnosis
  • Acute Kidney Injury* / epidemiology
  • Acute Kidney Injury* / etiology
  • Critical Illness*
  • Diagnosis, Differential
  • Disease Management*
  • Global Health
  • Humans
  • Incidence
  • Infant, Newborn
  • Risk Factors