Diastereoselective Synthesis of Functionalized Pyrrolidines Through N-bromosuccinimide-induced Aziridine Ring Expansion Cascade of Cinnamylaziridine

Org Biomol Chem. 2014 Oct 14;12(38):7482-5. doi: 10.1039/c4ob01384k.


An efficient aziridine ring expansion cascade of cinnamylaziridine has been developed. N-Bromosuccinimide was used as the promoter. The resulting functionalized pyrrolidines are the fundamental units of many useful molecules.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aziridines / chemistry*
  • Bromosuccinimide / chemistry*
  • Catalysis
  • Chemistry Techniques, Synthetic
  • Pyrrolidines / chemical synthesis*
  • Pyrrolidines / chemistry*
  • Stereoisomerism
  • Substrate Specificity


  • Aziridines
  • Pyrrolidines
  • aziridine
  • Bromosuccinimide