A smart and versatile theranostic nanomedicine platform based on nanoporphyrin

Nat Commun. 2014 Aug 26;5:4712. doi: 10.1038/ncomms5712.

Abstract

Multifunctional nanoparticles with combined diagnostic and therapeutic functions show great promise towards personalized nanomedicine. However, attaining consistently high performance of these functions in vivo in one single nanoconstruct remains extremely challenging. Here we demonstrate the use of one single polymer to develop a smart 'all-in-one' nanoporphyrin platform that conveniently integrates a broad range of clinically relevant functions. Nanoporphyrins can be used as amplifiable multimodality nanoprobes for near-infrared fluorescence imaging (NIRFI), magnetic resonance imaging (MRI), positron emission tomography (PET) and dual modal PET-MRI. Nanoporphyrins greatly increase the imaging sensitivity for tumour detection through background suppression in blood, as well as preferential accumulation and signal amplification in tumours. Nanoporphyrins also function as multiphase nanotransducers that can efficiently convert light to heat inside tumours for photothermal therapy (PTT), and light to singlet oxygen for photodynamic therapy (PDT). Furthermore, nanoporphyrins act as programmable releasing nanocarriers for targeted delivery of drugs or therapeutic radio-metals into tumours.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Cell Line, Tumor / drug effects
  • Dendrimers / chemistry
  • Doxorubicin / administration & dosage
  • Doxorubicin / chemistry
  • Drug Carriers / chemistry*
  • Drug Carriers / pharmacokinetics
  • Female
  • Fluorescence
  • Humans
  • Magnetic Resonance Imaging / methods
  • Male
  • Mice, Nude
  • Mice, Transgenic
  • Nanostructures / administration & dosage
  • Nanostructures / chemistry*
  • Nanostructures / therapeutic use*
  • Photochemotherapy / methods
  • Porphyrins / blood
  • Porphyrins / chemistry*
  • Porphyrins / pharmacokinetics
  • Rats, Sprague-Dawley
  • Reactive Oxygen Species / metabolism
  • Spectroscopy, Near-Infrared / methods
  • Theranostic Nanomedicine / instrumentation
  • Theranostic Nanomedicine / methods*

Substances

  • Dendrimers
  • Drug Carriers
  • Porphyrins
  • Reactive Oxygen Species
  • Doxorubicin