Abstract
Interactions between doxorubicin (DOX) and iron generate reactive oxygen species and contribute to DOX-induced heart failure. Hydrogen, as a selective antioxidant, is a promising potential therapeutic option for the treatment of a variety of diseases. Therefore, we investigated the preventive effects of hydrogen treatment on DOX-induced heart failure in rats. We found that cardiac function was significantly improved and that the plasma levels of oxidative-stress markers and myocardial autophagic activity were decreased in animals treated with hydrogen-containing saline. Therefore, we conclude that hydrogen-containing saline may have beneficial effects for doxorubicin-induced heart failure.
MeSH terms
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Animals
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Antibiotics, Antineoplastic / antagonists & inhibitors*
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Antibiotics, Antineoplastic / toxicity*
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Autophagy / drug effects
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Blotting, Western
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Cardiotonic Agents*
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Doxorubicin / antagonists & inhibitors*
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Doxorubicin / toxicity*
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Echocardiography
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Heart Failure / chemically induced*
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Heart Failure / diagnostic imaging
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Heart Failure / prevention & control*
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Hydrogen / chemistry
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Hydrogen / pharmacology*
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Male
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Microscopy, Electron, Transmission
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Myocardium / pathology
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Oxidative Stress / drug effects
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Pharmaceutical Solutions
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Rats
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Rats, Wistar
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Sodium Chloride / chemistry*
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Survival
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Ventricular Function, Left / drug effects
Substances
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Antibiotics, Antineoplastic
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Cardiotonic Agents
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Pharmaceutical Solutions
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Sodium Chloride
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Hydrogen
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Doxorubicin