Elevated plasma pentraxin 3 levels are associated with development and progression of diabetic retinopathy in Korean patients with type 2 diabetes mellitus

Invest Ophthalmol Vis Sci. 2014 Aug 26;55(9):5989-97. doi: 10.1167/iovs.14-14864.

Abstract

Purpose: To evaluate the association between elevated levels of plasma pentraxin 3 (PTX3) and the development and/or progression of diabetic retinopathy (DR).

Methods: In this case-control study, 92 diabetic patients with DR (group 3), 30 diabetic patients without DR (group 2), and 41 normal subjects (group 1) were enrolled. Log-transformed values of plasma PTX3 and high-sensitivity C-reactive protein (hsCRP) concentrations were measured and used in our analysis. For subgroup analysis, group 3 was divided into four subgroups: mild, moderate, severe nonproliferative, and proliferative DR.

Results: In our 163 participants, average plasma PTX3 levels were 916.1 ± 532.2, 1093.7 ± 1034.2, and 1817.9 ± 1776.9 pg/mL for groups 1, 2, and 3, respectively. The duration of diabetic mellitus (DM), glycated hemoglobin (HbA1c), log hsCRP, and log PTX3 were significantly different between the three groups (P = 0.008, P < 0.001, P = 0.046, and P < 0.001, respectively). In subgroup analysis, plasma log PTX3 levels increased in correlation with the severity of DR (R = 0.372, P < 0.001). Multivariate logistic analysis showed that the correlation between DR development and duration of DM and log PTX3 values was significant (P = 0.014 and P = 0.025, respectively), whereas correlation with log hsCRP values was not significant in univariate analysis (P = 0.129). The receiver operating characteristic curves of DR development were plotted using log PTX3 and log hsCRP values, and the area under the curves was found to be 0.721 (P = 0.001) and 0.614 (P = 0.087), respectively.

Conclusions: Plasma PTX3 is positively associated with DR development and progression, and may be a more accurate predictor of DR development than hsCRP.

Keywords: C-reactive protein; diabetes mellitus; diabetic retinopathy; pentraxin 3.

MeSH terms

  • Aged
  • Asian People
  • Biomarkers / blood
  • C-Reactive Protein / immunology
  • C-Reactive Protein / metabolism*
  • Case-Control Studies
  • Diabetes Mellitus, Type 2 / immunology
  • Diabetes Mellitus, Type 2 / metabolism*
  • Diabetic Retinopathy / diagnosis
  • Diabetic Retinopathy / immunology
  • Diabetic Retinopathy / metabolism*
  • Disease Progression
  • Female
  • Humans
  • Male
  • Microcirculation / immunology
  • Middle Aged
  • Predictive Value of Tests
  • Sensitivity and Specificity
  • Serum Amyloid P-Component / immunology
  • Serum Amyloid P-Component / metabolism*
  • Severity of Illness Index*
  • Vasculitis / diagnosis
  • Vasculitis / immunology
  • Vasculitis / metabolism*

Substances

  • Biomarkers
  • Serum Amyloid P-Component
  • PTX3 protein
  • C-Reactive Protein