Prospective Assessment of an innovative test for prostate cancer screening using the VITA process model framework

Stud Health Technol Inform. 2014;205:236-40.


Healthcare innovations are crucial for enhancing patient treatment and a high-quality healthcare system. However, bringing new technologies, methods and procedures into the healthcare market is challenging. Enormous amounts of financial, personnel and organizational resources are required with no upfront certainty for the medical and economic benefit. A new and innovative approach uses interdisciplinary medical, technical and economic expertise to forecast effects of healthcare innovations already at the early research and concept phase of an idea and before major investments are made. A process model framework was developed to operationalize this structured assessment of healthcare innovations. The Visionary Iterative Tailored Approach (VITA) is based on conceptual modeling, simulation and health economics evaluation. Its application for the prospective assessment of an innovative prostate cancer screening is presented.

Publication types

  • Evaluation Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biomarkers, Tumor / blood*
  • Computer Simulation
  • Cost-Benefit Analysis
  • Early Detection of Cancer / economics*
  • Germany / epidemiology
  • Health Care Costs / statistics & numerical data
  • Humans
  • Male
  • Models, Economic*
  • Prevalence
  • Prospective Studies
  • Prostate-Specific Antigen / blood*
  • Prostatic Neoplasms / diagnosis*
  • Prostatic Neoplasms / economics*
  • Prostatic Neoplasms / epidemiology
  • Reproducibility of Results
  • Sensitivity and Specificity
  • Technology Assessment, Biomedical / economics
  • Technology Assessment, Biomedical / methods*


  • Biomarkers, Tumor
  • Prostate-Specific Antigen