Molecular pathology - the value of an integrative approach

Mol Oncol. 2014 Oct;8(7):1163-8. doi: 10.1016/j.molonc.2014.07.021. Epub 2014 Aug 12.


Molecular Pathology (MP) is at the heart of modern diagnostics and translational research, but the controversy on how MP is best developed has not abated. The lack of a proper model or trained pathologists to support the diagnostic and research missions makes MP a rare commodity overall. Here we analyse the scientific and technology areas, in research and diagnostics, which are encompassed by MP of solid tumours; we highlight the broad overlap of technologies and analytical capabilities in tissue research and diagnostics; and we describe an integrated model that rationalizes technical know-how and pathology talent for both. The model is based on a single, accredited laboratory providing a single standard of high-quality for biomarker discovery, biomarker validation and molecular diagnostics.

Keywords: Molecular diagnostics; Molecular pathology; Translational research.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Biomarkers, Tumor / analysis
  • Computational Biology / methods
  • Humans
  • Neoplasms / diagnosis*
  • Neoplasms / pathology
  • Pathology, Molecular / methods*
  • Tissue Banks
  • Translational Research, Biomedical / methods*


  • Biomarkers, Tumor