[Iron and regulatory proteins in the normal and pathological retina]

Bull Acad Natl Med. 2013 Mar;197(3):661-74; discussion 674-5.
[Article in French]


Iron is necessary for cell metabolism, but excess iron can be toxic Iron can generate oxygen free radicals through the Fenton reaction. Iron accumulation has been observed in the retina of patients with age-related macular degeneration (AMD). We have shown its accumulation in photoreceptor segments in two animal models of genetic retinal degeneration (RCS rats and Rd10 mice). In these rodents, hTf, injected intraperitoneally or expressed by genetic modification, delayed photoreceptor degeneration. Our studies highlight the therapeutic potential of Tf in degenerative processes such as retinitis pigmentosa and AMD.

Publication types

  • English Abstract

MeSH terms

  • Animals
  • Disease Models, Animal
  • Humans
  • Iron / metabolism*
  • Iron-Regulatory Proteins / metabolism*
  • Mice
  • Rats
  • Retina / metabolism*
  • Retinal Degeneration / genetics
  • Retinal Degeneration / metabolism*
  • Retinal Degeneration / pathology


  • Iron-Regulatory Proteins
  • Iron