Safety Assessment of PEGylated oils as used in cosmetics

Int J Toxicol. 2014 Nov-Dec;33(4 Suppl):13S-39S. doi: 10.1177/1091581814546337. Epub 2014 Aug 27.


PEGylated oil is a terminology used to describe cosmetic ingredients that are the etherification and esterification products of glycerides and fatty acids with ethylene oxide. The Cosmetic Ingredient Review Expert Panel (Panel) considered the safety of PEGylated oils, which function primarily as surfactants in cosmetic products. The Panel reviewed relevant animal and human data provided in this safety assessment and concluded that the 130 chemically related PEGylated oils were safe as cosmetic ingredients in the present practices of use and concentration when formulated to be nonirritating.

Keywords: PEGylated oils; cosmetics; safety.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Castor Oil / analogs & derivatives*
  • Castor Oil / toxicity
  • Consumer Product Safety
  • Cosmetics / toxicity*
  • Dermatitis, Irritant / etiology*
  • Humans
  • Polyethylene Glycols / toxicity*
  • Risk Assessment
  • Surface-Active Agents / toxicity*
  • United States


  • Cosmetics
  • Surface-Active Agents
  • Polyethylene Glycols
  • polyethoxylated castor oil
  • Castor Oil