Microdissection approaches in tuberculosis research

J Med Primatol. 2014 Oct;43(5):294-7. doi: 10.1111/jmp.12141. Epub 2014 Aug 28.


Mycobacterium tuberculosis, a globally significant pathogen, results in active or latent tuberculosis. The granuloma is the characteristic lesion that offers insight into host-pathogen interactions in these distinct states. Microdissection provides a way to isolate and consequently investigate specific tissue sections. We review various techniques available and in use.

Keywords: Mycobacterium tuberculosis; dissection; granuloma; mesodissection; non-human primate.

Publication types

  • Review

MeSH terms

  • Animals
  • Disease Models, Animal*
  • Granuloma / microbiology
  • Host-Pathogen Interactions
  • Humans
  • Microdissection*
  • Microscopy, Confocal
  • Mycobacterium tuberculosis / physiology*
  • Primates*
  • Tuberculosis / microbiology*
  • Tuberculosis / physiopathology