Fifteen patients with carcinoma of the pancreas were treated with intratumoral injection of mitomycin-C adsorbed by activated carbon particles (MMC-CH) under ultrasound guidance. Following the treatment, in 6 out of 13 patients, the serum CA 19-9 declined to 10-75% of that before the treatment. The pain was alleviated in 8 out 13 patients, and in 5 out of 8 of these patients the serum CA 19-9 declined. In one case treated with MMC-CH before total pancreatectomy, charcoal deposits were found in the tumor and in 17 regional lymph nodes along with degeneration of cancer cells around the deposited charcoal. The results indicate that intratumoral injection of MMC-CH might be one of the methods for the treatment of advanced pancreatic cancer.