Role and therapeutic value of dendritic cells in central nervous system autoimmunity

Cell Death Differ. 2015 Feb;22(2):215-24. doi: 10.1038/cdd.2014.125. Epub 2014 Aug 29.


Dendritic cells (DCs) are professional antigen-presenting cells that control the generation of adaptive immunity. Consequently, DCs have a central role in the induction of protective immunity to pathogens and also in the pathogenic immune response responsible for the development and progression of autoimmune disorders. Thus the study of the molecular pathways that control DC development and function is likely to result in new strategies for the therapeutic manipulation of the immune response. In this review, we discuss the role and therapeutic value of DCs in autoimmune diseases, with a special focus on multiple sclerosis.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adaptive Immunity
  • Antigen-Presenting Cells / immunology*
  • Autoimmune Diseases / immunology
  • Autoimmunity*
  • Central Nervous System / immunology*
  • Dendritic Cells / classification
  • Dendritic Cells / immunology*
  • Humans
  • Interleukin-27 / immunology
  • Multiple Sclerosis / immunology*
  • Vaccination


  • Interleukin-27