Induction of lymphoma in CDF1 mice by the food mutagen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine

Jpn J Cancer Res. 1989 Dec;80(12):1176-8. doi: 10.1111/j.1349-7006.1989.tb01651.x.


The mutagenic compound, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), originally isolated from cooked beef, was tested for carcinogenicity in CDF1 mice of both sexes. When PhIP was given in the diet at a concentration of 0.04%, high incidences and early appearances of lymphomas were observed in both sexes during the 579-day experiment.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Female
  • Imidazoles*
  • Lymphoma / chemically induced*
  • Male
  • Mice
  • Mice, Inbred Strains
  • Mutagens*


  • Imidazoles
  • Mutagens
  • 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine