The pathogenesis of focal segmental glomerulosclerosis

Adv Chronic Kidney Dis. 2014 Sep;21(5):408-16. doi: 10.1053/j.ackd.2014.05.009.


Focal segmental glomerulosclerosis (FSGS) is a histologic pattern of injury on kidney biopsy that can arise from a diverse range of causes and mechanisms. Although primary and secondary forms are described based on the underlying cause, there are many common factors that underlie the development of this segmental injury. In this review, we will describe the currently accepted model for the pathogenesis of classic FSGS and review the data supporting this model. Although the podocyte is considered the major target of injury in FSGS, we will also highlight the contributions of other resident glomerular cells in the development of FSGS.

Keywords: Focal segmental glomerulosclerosis; Glomerular disease; Parietal epithelial cell; Podocyte; Proteinuria.

Publication types

  • Review

MeSH terms

  • Glomerulosclerosis, Focal Segmental / etiology
  • Glomerulosclerosis, Focal Segmental / pathology*
  • Humans
  • Kidney Glomerulus / pathology*
  • Podocytes / metabolism
  • Podocytes / pathology*
  • Receptors, Urokinase Plasminogen Activator / genetics
  • Stress, Mechanical


  • Receptors, Urokinase Plasminogen Activator