Transient Substrate-Induced Catalyst Formation in a Dynamic Molecular Network

Angew Chem Int Ed Engl. 2014 Oct 13;53(42):11346-50. doi: 10.1002/anie.201403480. Epub 2014 Aug 28.


In biology enzyme concentrations are continuously regulated, yet for synthetic catalytic systems such regulatory mechanisms are underdeveloped. We now report how a substrate of a chemical reaction induces the formation of its own catalyst from a dynamic molecular network. After complete conversion of the substrate, the network disassembles the catalyst. These results open up new opportunities for controlling catalysis in synthetic chemical systems.

Keywords: aza-Cope rearrangement; combinatorial chemistry; dynamic molecular networks; supramolecular chemistry; systems chemistry.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biocatalysis
  • Catalysis
  • Combinatorial Chemistry Techniques / methods*
  • Systems Theory