Construction of an Effective Landscape for Multistate Genetic Switches

Phys Rev Lett. 2014 Aug 15;113(7):078102. doi: 10.1103/PhysRevLett.113.078102. Epub 2014 Aug 13.

Abstract

Multistate genetic switches play a crucial role during embryonic development and tumorigenesis. An archetypical example is the three-way switch regulating epithelial-hybrid-mesenchymal transitions. We devise a special WKB-based approach to investigate white Gaussian and shot noise effects on three-way switches, and construct an effective landscape in good quantitative agreement with stochastic simulations. This approach allows efficient analytical or numerical calculation of the landscape contours, the optimal path, and the state relative stability for general multicomponent multistate switches.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Carcinogenesis / genetics
  • Embryonic Development / genetics
  • Epithelial-Mesenchymal Transition / genetics
  • Genes, Switch*
  • Models, Genetic*