Chemical composition and antibacterial activity of Lavandula coronopifolia essential oil against antibiotic-resistant bacteria

Nat Prod Res. 2015;29(6):582-5. doi: 10.1080/14786419.2014.954246. Epub 2014 Aug 30.


The aim of this study was to analyse the composition of the essential oil (EO) of Lavandula coronopifolia from Morocco and to evaluate its in vitro antibacterial activity against antibiotic-resistant bacteria isolated from clinical infections. The antimicrobial activity was assessed by a broth micro-well dilution method using multiresistant clinical isolates of 11 pathogenic bacteria: Klebsiella pneumoniae subsp. pneumoniae, Klebsiella ornithinolytica, Escherichia coli, Enterobacter cloacae, Enterobacter aerogenes, Providencia rettgeri, Citrobacter freundii, Hafnia alvei, Salmonella spp., Acinetobacter baumannii and methicillin-resistant Staphylococcus aureus. The main compounds of the oil were carvacrol (48.9%), E-caryophyllene (10.8%) and caryophyllene oxide (7.7%). The oil showed activity against all tested strains with minimal inhibitory concentration (MIC) values ranging between 1% and 4%. For most of the strains, the MIC value was equivalent to the minimal bactericidal concentration value, indicating a clear bactericidal effect of L. coronopifolia EO.

Keywords: Lavandula coronopifolia; antibacterial activity; essential oil; multiresistant bacteria.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Cymenes
  • Drug Resistance, Multiple, Bacterial / drug effects*
  • Lavandula / chemistry*
  • Microbial Sensitivity Tests
  • Monoterpenes / chemistry
  • Morocco
  • Oils, Volatile / chemistry
  • Oils, Volatile / pharmacology*
  • Plant Oils / chemistry
  • Plant Oils / pharmacology*
  • Polycyclic Sesquiterpenes
  • Sesquiterpenes / chemistry


  • Anti-Bacterial Agents
  • Cymenes
  • Monoterpenes
  • Oils, Volatile
  • Plant Oils
  • Polycyclic Sesquiterpenes
  • Sesquiterpenes
  • carvacrol
  • caryophyllene
  • caryophyllene oxide