Vitamin E and D regulation of allergic asthma immunopathogenesis

Int Immunopharmacol. 2014 Nov;23(1):364-72. doi: 10.1016/j.intimp.2014.08.007. Epub 2014 Aug 29.


Asthma occurs as complex interactions of the environmental and genetics. Clinical studies and animal models of asthma indicate dietary factors such as vitamin E and vitamin D as protective for asthma risk. In this review, we discuss opposing regulatory functions of tocopherol isoforms of vitamin E and regulatory functions of vitamin D in asthma and how the variation in global prevalence of asthma may be explained, at least in part, by these dietary components.

Keywords: Animal models; Asthma; Human; Vitamin D; α-Tocopherol; γ-Tocopherol.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Asthma / diet therapy
  • Asthma / immunology*
  • Clinical Trials as Topic
  • Dietary Supplements
  • Humans
  • Hypersensitivity / diet therapy
  • Hypersensitivity / immunology*
  • Respiration
  • Signal Transduction
  • Vitamin D / metabolism*
  • Vitamin E / metabolism*


  • Vitamin D
  • Vitamin E