Adenosine receptor PET imaging in human brain

Masahiro Mishina; Kiich Ishiwata

doi:10.1016/B978-0-12-801022-8.00002-7

Adenosine receptor PET imaging in human brain

Int Rev Neurobiol. 2014:119:51-69. doi: 10.1016/B978-0-12-801022-8.00002-7.

Authors

Masahiro Mishina¹, Kiich Ishiwata²

Affiliations

¹ Department of Neurological Science, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan; Research Team for Neuroimaging, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan. Electronic address: mishina@nms.ac.jp.
² Research Team for Neuroimaging, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan.

PMID: 25175960
DOI: 10.1016/B978-0-12-801022-8.00002-7

Abstract

Positron emission tomography (PET) is a nuclear medicine imaging technique that allows in vivo imaging of regional receptor-binding capacity. Advances in radiotracer chemistry have led to the development of novel imaging probes for adenosine receptors, especially adenosine A1 and A2A receptors. In this chapter, we discuss brain PET imaging for adenosine receptors and comparison of radioligands for PET imaging in health and diseases.

Keywords: Adenosine A(1) receptor; Adenosine A(2A) receptor; Molecular imaging.

Publication types

Review

MeSH terms

Brain / diagnostic imaging*
Brain / metabolism*
Humans
Positron-Emission Tomography*
Receptors, Purinergic P1 / metabolism*

Substances

Receptors, Purinergic P1