Stem cell competition: how speeding mutants beat the rest

EMBO J. 2014 Oct 16;33(20):2277-8. doi: 10.15252/embj.201489823. Epub 2014 Sep 1.

Abstract

How mutations lead to tumor formation is a central question in cancer research. Although cellular changes that follow the occurrence of common mutations are well characterized, much less is known about their effects on the population level. Now, two recent studies reveal in what way oncogenic aberrations alter stem cell dynamics to provide cells with an evolutionary advantage over their neighbors (Amoyel et al, ; Baker et al, 2014).

Publication types

  • Comment

MeSH terms

  • Animals
  • Drosophila Proteins / genetics*
  • Drosophila Proteins / metabolism*
  • Hedgehog Proteins / metabolism*
  • Intracellular Signaling Peptides and Proteins / metabolism*
  • Male
  • Protein Serine-Threonine Kinases / metabolism*
  • Receptors, Cell Surface / genetics*
  • Stem Cell Niche / physiology*
  • Stem Cells / physiology*

Substances

  • Drosophila Proteins
  • Hedgehog Proteins
  • Intracellular Signaling Peptides and Proteins
  • Receptors, Cell Surface
  • ptc protein, Drosophila
  • hh protein, Drosophila
  • Protein Serine-Threonine Kinases
  • hpo protein, Drosophila