Dynamic alterations occur in the levels and composition of transcription factor AP-1 complexes after seizure

Neuron. 1989 Sep;3(3):359-65. doi: 10.1016/0896-6273(89)90260-2.


Seizure causes a rapid and protracted increase in transcription factor AP-1 levels in the brain. The composition of AP-1 nucleoprotein complexes changes with time after seizure as a result of the sequential appearance and disappearance of Fos and several Fos-related proteins. Although these changes occur over an 8 hr time period, they are triggered by 15 min of seizure. Alterations in the levels and composition of transcription factors may represent one of the molecular mechanisms underlying neuronal adaptation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Benzodiazepines / pharmacology
  • DNA-Binding Proteins / metabolism*
  • Gene Expression Regulation
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Pentylenetetrazole
  • Proto-Oncogene Proteins / metabolism
  • Proto-Oncogene Proteins c-jun
  • Seizures / chemically induced
  • Seizures / genetics
  • Seizures / metabolism*
  • Transcription Factors / metabolism*


  • DNA-Binding Proteins
  • Proto-Oncogene Proteins
  • Proto-Oncogene Proteins c-jun
  • Transcription Factors
  • Benzodiazepines
  • Pentylenetetrazole