Modern genome editing meets telomeres: the many functions of TPP1

Genes Dev. 2014 Sep 1;28(17):1857-8. doi: 10.1101/gad.250316.114.


The telomeric complex has been analyzed in detail for its role in regulating telomere protection and telomere length. Now, modern genome-editing techniques in human embryonic stem cells reveal TPP1 as the essential recruitment factor for telomerase, with additional functions in telomerase activation and definition of telomere length homeostasis.

Keywords: embryonic stem cells; human genome engineering; shelterin; telomerase; telomere maintenance.

Publication types

  • Comment

MeSH terms

  • Aminopeptidases / metabolism*
  • Dipeptidyl-Peptidases and Tripeptidyl-Peptidases / metabolism*
  • Humans
  • Serine Proteases / metabolism*
  • Telomerase / metabolism*
  • Telomere / enzymology*
  • Telomere Homeostasis / genetics*


  • Telomerase
  • Serine Proteases
  • Aminopeptidases
  • Dipeptidyl-Peptidases and Tripeptidyl-Peptidases
  • tripeptidyl-peptidase 1